Evaluation of Trace Elements and Antioxidants in Pre and Post Hemodialysis of Chronic Renal Failure Patients

Oxidative stress is related to several diseases, including chronic renal insufficiency. The lipid peroxidation in hemolysis patients may be partly due to the trace elements disturbances. It has been mentioned that during hemolysis there are relations between deficiency in trace elements and antioxidant levels. The present study was carried out to evaluate the differences between hemodialysis patients and control group according to selenium (Se), aluminium (Al), Zinc (Zn), Copper (Cu), Manganese (Mn), malondialdyhyde (MDA), reduced form glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity levels. The study comprised with 25 hemodialysis patients. The blood samples were taken before and after hemodialysis session. The control group included 11 healthy volunteers. SOD, CAT, (Al) and MDA levels showed significant increase and GSH, Cu, Mn and Zn levels were significant reduced in pre-hemodialysis group when compared with the controls. Moreover, after hemodialysis, the levels of SOD, CAT, (Al) and MDA were significantly elevated and (Cu, Mn and Zn) levels were decreased compared to the control group. On the other hand, no significant changes in the values of GSH and (Se) between control and after dialysis process. From our findings, we concluded that there may be a relation between increased antioxidant enzyme activity levels and MDA and trace elements in chronic renal failure patients. In addition, the levels of aluminium can be used as an important marker in hemodialysis patients.